Medical Note Book

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Cesarean Birth Linked to Higher ICU Admission Risk Than Vaginal Birth ▫️Intrapartum Cesarean Birth And Intended Cesarean Birth Were Associated With Higher Odds of ICU Admission Compared to Vaginal Birth. ▫️It Was Published Online on August 10 in Anesthesia and Analgesia. @MedicalNoteBook

Urinary Drug Tadalafil Linked to Glaucoma Risk ▫️A Multinational Cohort Study Found The Use of Tadalafil, A Phosphodiesterase Type 5 (PDE5) Inhibitor, For Lower Urinary Tract Symptoms Was Associated With A 22% Higher Risk For Glaucoma Over 5 Years Than Non-PDE5 Inhibitor Use. ▫️Using Tadalafil Was Also Associated With Higher Risks For Ocular Hypertension, Primary Open-Angle Glaucoma, And Initiation of Treatment For Glaucoma. @MedicalNoteBook

CDC Records More Than 2,500 Measles Cases So Far in 2026 ▫️The US Centers For Disease Control And Prevention (CDC) Said on Friday There Were 2,566 Confirmed ⁠Measles Cases in The Country So Far This Year, Expanding The Highest Annual Total in More Than ⁠35 Years. ▫️The Overall 2026 Figures Represent The Highest Number of ⁠US Cases in A Single ‌Year Since A Major Resurgence of The Highly Contagious Disease in The Period From 1989 to 1991, With More Than 55,000 Infections And 123 Deaths. ▫️As Many As 93% ‌of This Year's Cases Were ‌in Unvaccinated Individuals or People Whose Vaccination Status Was Unknown, With The Rest Having Received One ⁠or Two doses of Vaccine Before Being ‌Infected, The CDC Said. @MedicalNoteBook

New Lab-Grown Heart Valves Advance Treatments For Childhood Heart Diseases ▫️Melbourne Researchers Have Created Human Heart Valve Tissues From Stem Cells, Providing A Powerful New Platform to Advance Treatments For Childhood Heart Diseases. ▫️The World-First Discovery, Led by Murdoch Children's Research Institute (MCRI), Has Produced Lab Grown Heart Valve Tissues That Closely Resemble Those in The Human Body. ▫️Published in Cell Stem Cell, The Findings Advance Our Understanding Into How Human Heart Valves Develop, Mature And Become Damaged. @MedicalNoteBook

Women Taking Estrogen Had Fewer Signs of Alzheimer’s in Their Brains ▫️A Large Study Has Found That Women Who Used Hormone Therapy Later in Life Had A Lower Risk of Developing Dementia. ▫️The Findings Were Published August 12, 2026, in Neurology, The Medical Journal of The American Academy of Neurology. @MedicalNoteBook

Antiviral Treatment Lowers ICU Risk For Children With Influenza ▫️A New Nationwide Study Finds Antiviral Treatment Is Linked to Fewer Intensive Care Unit (ICU) Admissions And Shorter Hospital Stays For Children Hospitalized With Influenza. ▫️The Research Found That Children Who Received Early Treatment With Antiviral Treatment, in This Case Oseltamivir, Were 31% Less Likely to Be Admitted to An ICU And Had Shorter Hospital Stays Than Those Who Did Not Receive The Antiviral. ▫️The Study, Published in JAMA Pediatrics And Led by Experts at The University of Colorado Anschutz, Is One of The Most Comprehensive Real-World Evaluations of Antiviral Treatment in Pediatric Influenza to Date. @MedicalNoteBook

Continuing Antidepressants During Pregnancy Linked to Lower Postpartum Depression Risk ▫️Continuing Antidepressant Medications During Pregnancy Is Associated With A Lower Postpartum Depression Risk in Women With A History of Depression Than Stopping or Stopping And Then Restarting Medication. ▫️It Was Published Online in The American Journal of Obstetrics & Gynecology. @MedicalNoteBook

FDA Approved Orzeyful For Adults With Narcolepsy Type 1 ▫️The US Food And Drug Administration (FDA) Has Approved Orzeyful (Oveporexton) Tablets For The Treatment of Narcolepsy Type 1 (NT1) in Adults. ▫️Orzeyful Is The First Medicine Approved For Narcolepsy Type 1 As A Complete Disorder - Addressing The Full Range of Symptoms That Define The Condition - And The First to Work by Directly Targeting The Loss of Orexin Signaling That Causes The Disease. ▫️It Is Taken Orally Twice Daily And Is Contraindicated in Patients Taking Strong CYP3A Inhibitors. Its Safety And Effectiveness Have Not Been Established in Patients Younger Than 18 Years. ▫️NT1 Is A Rare, Chronic Disorder Caused by Loss of Orexin Neurons, Which Are Involved in Sleep Regulation. Hallmarks of The Disorder Include Excessive Daytime Sleepiness, Cataplexy, Disrupted Nighttime Sleep, Sleep Paralysis, As Well As Cognitive Difficulties. @MedicalNoteBook

No Intramuscular Vitamin K Shot at Birth Linked to Higher Bleeding Risk in Infants ▫️The Proportion of Infants With Undocumented Intramuscular Vitamin K Administration at Birth in Sweden Decreased Initially But Increased From 0.66% in 2006 to 1.50% in 2021. ▫️Infants Who Did Not Receive This Prophylaxis Had Increased Odds of Bleeding And Intracranial Hemorrhage Within The First 6 Months of Life, With Oral Vitamin K Also Linked to An Elevated Risk For Bleeding Compared With Intramuscular Administration. ▫️It Was Published Online On July 13, 2026, in JAMA Pediatrics. @MedicalNoteBook

EC Approved Datroway As First-Line Metastatic Triple-Negative Breast Cancer ▫️AstraZeneca And Japanese Partner Daiichi Sankyo’s Datroway (Datopotamab Deruxtecan) Has Been Approved by The European Commission (EC) As Monotherapy For The 1st-Line Treatment of Adult Patients With Unresectable or Metastatic Triple-Negative Breast Cancer (TNBC) Who Are Not Candidates For PD-1/PD-L1 Inhibitor Therapy. ▫️The Antibody-Drug Conjugate (ADC) Is Also Approved in The EU As A Second-Line Therapy For Unresectable or Metastatic HR-Positive, HER2-Negative Breast Cancer. @MedicalNoteBook

FDA Approved Gedatolisib For Hormone Receptor-Positive Breast Cancer ▫️The FDA Has Approved Gedatolisib (Revtorpyk) Plus Fulvestrant (Faslodex), With or Without Palbociclib (Ibrance), For The Treatment of Adult Patients With Hormone Receptor–Positive, HER2-Negative Advanced Breast Cancer Without A PIK3CA Mutation Following Progression On or After Treatment With 1 or More Lines of Endocrine Therapy in The Metastatic Setting. @MedicalNoteBook

EC Approved Opzelura For Moderate Atopic Dermatitis ▫️The European Commission (EC) Has Approved Opzelura (Ruxolitinib) Cream For The Treatment of Moderate Atopic Dermatitis (AD) in Adult Patients For Whom Topical Corticosteroids (TCSs) And Topical Calcineurin Inhibitors (TCIs) Are Inadequate or Inappropriate, US Biopharma Incyte Announced. @MedicalNoteBook

EC Expands Crysvita Approval to Infants With Rare Phosphate Disorder ▫️The European Commission (EC) Has Approved An Expanded Indication For Japan-Based Pharma Company Kyowa Kirin’s Crysvita (Burosumab), Allowing The Medicine to Be Used in Infants From One Month to Under One Year of Age With X-Linked Hypophosphatemia (XLH). ▫️This Decision Follows A Positive Opinion From The European Medicines Agency’s Committee For Medicinal Products For Human Use (CHMP) in April 2026 And Extends The Use of The Fibroblast Growth Factor 23 (FGF23)-Targeting Monoclonal Antibody in The European Union (EU). ▫️XLH Is Characterised by Phosphate Wasting, Which Disrupts Bone Mineralisation And Can Result in Skeletal Deformities, Impaired Growth, And Additional Complications. @MedicalNoteBook

FDA Approved First NDSRI For ADHD in Adults And Children ▫️The FDA Has Approved Centanafadine (Simtriyo, Otsuka) As A First-in-Class Treatment of Attention-Deficit/Hyperactivity Disorder (ADHD) in Adult And Pediatric Patients.  ▫️The Once-Daily Extended-Release Capsule Is Approved For Adults And Children Aged 6 Years And Older Who Weigh at Least 2 0kg (44.1 lb). It Is The Only Norepinephrine, Dopamine, Serotonin Reuptake Inhibitor (NDSRI) Approved For This Indication, The Company Reported in A Statement. @MedicalNoteBook

Early-Life Respiratory Infection Burden Linked to Higher Childhood Atopic Dermatitis Risk ▫️Children With A High Burden of Infections Through Age 3 Showed A Greater Risk of Developing Atopic Dermatitis (AD) in A Large Danish Cohort Study. ▫️The Study Was Published Online On July 29 in JAMA Dermatology. @MedicalNoteBook

FDA Approved New Once-Weekly Birth Control Patch Gwyn Lo ▫️The FDA Has Approved Gwyn Lo (Viatris), A New Birth Control Patch That Uses Low-dose Estrogen to Prevent Pregnancy. ▫️The Patch Is Designed For Once-Weekly Administration And Delivers The Hormones Norelgestromin (220 μg/day) And Ethinyl Estradiol (20 μg/day) Directly Through The Skin. It Is Applied Once Weekly For 3 Consecutive Weeks, Followed by 1 Patch-Free Week. ▫️Gwyn Lo Is Approved For Women With A BMI Below 30 Who Are Appropriate Candidates For Combined Hormonal Contraceptives, According to A Release From Viatris. @MedicalNoteBook

Ischemic Heart Disease And Cerebrovascular Disease Linked to Increased Parkinson's Disease ▫️Women With Prior Ischemic Heart Disease (IHD) or Cerebrovascular Disease Had A Higher Long-Term Risk For Parkinson's Disease (PD) in A Study. ▫️It Was Published Online on July 24 in Annals of Clinical and Translational Neurology. @MedicalNoteBook

Magic Mushrooms May Reshape The Brain Long After The Trip Ends ▫️A Single dose of Psilocybin, The Psychedelic Substance in Magic Mushrooms, May Produce Physical Changes in The Brain That Remain Detectable For As Long As A Month, According to Researchers at UC San Francisco And Imperial College London. ▫️The Study, Published in Nature Communications, Involved Healthy Adults Who Had Never Previously Used A Psychedelic. @MedicalNoteBook

FDA Approved First-Ever Freeze-Dried Plasma Product ▫️The US Food And Drug Administration (FDA) On Wednesday Licensed The Nation’s First Freeze-Dried Plasma Product For Transfusion, Clearing The Way For Its Use in Military Operations, Disaster Areas And Other Locations Where Conventional Frozen Plasma Is Unavailable. ▫️The Product, Known As Ezplaz Freeze Dried Plasma, Is Intended For Transfusion in Adult Patients Who Require Plasma When Standard Plasma Products Cannot Be Obtained, The Agency Said. ▫️Unlike Conventional Plasma, Which Must Remain Frozen Until Shortly Before Use, Ezplaz Is Freeze-Dried Through A Lyophilization Process And Is Supplied As A Complete Transfusion Kit. ▫️Each Package Contains One Unit of Plasma, A 250-Milliliter Bag of Sterile Water For Injection, A Sterile Fluid Transfer Set And A Blood Transfusion Set. @MedicalNoteBook