Open Longevity

On April 8, 2026 longevity advocates will rally to fight aging. The event is organized by the FUND LONGEVITY group, lots of other orgs are joining. This is a coordinated multi-city effort to bring life extension into the mainstream conversation. If you believe aging should be solved, this is an opportunity to actually do something about it. You can join a rally in person or follow the event via livestream. Cities currently joining the rallies 🇳🇱 Amsterdam 🇩🇪 Berlin 🇧🇪 Brussels 🇬🇧 London 🇪🇸 Madrid 🇫🇷 Paris 🇮🇹 Rome 🇸🇪 Stockholm Livestream Viewers will be able to follow rallies from multiple cities and hear from scientists and longevity leaders including: Aubrey de Grey Alexander Panchin Peter Lidsky Laurence Ion Hosted by Nastya Egorova. Additional speakers will be announced. Why rally against aging? Aging remains the largest driver of death and disease worldwide. Approximately 110,000 people die every day from age-related causes. Aging is the primary risk factor behind cancer, heart disease, Alzheimer’s disease, and most chronic illnesses. Greater public awareness and political attention are needed to accelerate progress. Participants will gather near parliaments and other centers of political influence. Public visibility can help shift priorities toward supporting longevity science and biomedical innovation. What needs to change A meaningful societal commitment to longevity science requires: • Major increases in funding for basic aging research • Regulatory pathways for therapies that target aging

JOBS IN LONGEVITY Job Position: Venture Scout (Longevity) Company: Versetti Family Office Work: Remote Job type: Contract Salary: $2,000–4,000 About us We are a lean and frugal family office founded by the serial entrepreneur Angel Versetti. Our private investment fund is seeking promising early-stage startups in longevity to invest in and accelerate. versetti.co Specific responsibilities: • Identify Deal-flows and Cultivate Relationships in longevity space: Develop and maintain strong relationships with startups, entrepreneurial scientists, venture capitalists (VCs), family offices, and investment syndicates. • Market Awareness: Stay abreast of the latest trends and developments in longevity, providing insights and recommendations to keep the project at the forefront of industry advancements. • Representation at events: attend industry events with the purpose of seeking out existing startups or pre-startups (research projects that could be transformed into startups) • Managing speaking opportunities for the Founder at these conferences or events. • Helping develop a business model for a holding company with focus on longevity. Focus on acquisitions of technologies, R&D or startups. • Other administrative or logistical tasks related to the broader operations of the fund and its projects may be given at any point of time. Requirements for candidate: • The ideal candidate will have deep personal passion for longevity and understanding of early stage startups. This individual should also have experience reaching out WITH RESULTS to large number of warm leads, managing people and to be an effective communicator. • Be prepared for a chaotic, unpredictable, non-linear environment with unconventional tasks and problems. You need to be a self-starter and able to work in a dynamic environment with minimal hand-holding. • We need an ability to be mobile and responsive and never say to any task "this is a job for another person". There are no tasks "too unimportant for my level". Please note this is a remote position (fixed contract), with no office provided. Company is located off-shore. Team is remote and converges at various conferences for in-person meetings. WE DO NOT OFFER VISA SPONSORSHIP OR RELOCATION ASSISTANCE. Qualifications: • At least MSc in longevity-related STEM (biology, medicine, pharmacology, biochemistry, genomics, computational biology) • Preferable experience in early-stage or growth-stage startups or at least research projects that secured grants, prizes or other non-equity funding • Network and Charisma: Possess an extensive network within the longevity community, showcasing the ability to leverage connections to find interesting startups • Intelligent use of auxiliary AI tools • Strong communication skills. • Perfect English is a must. Working/native knowledge of other major global languages is a plus. • Experience working with a team in a non-corporate environment. We do NOT have various standard corporate processes in place! Contact info:  - https://t.me/swordfishthrombone - admin@versetti.co

We published a book! It's an overview of current longevity research, dense with facts and full of stories and cultural references. We honestly think this book turned out to be a great starting point providing a good solid basis, covering both biohacking and more serious therapies, calorie restriction and cellular reprograming, philosophy and extracellular matrix... among other topics! Three years of work by [mostly] Alexander Panchin and our team [as much as we could]. We are beyond grateful to all the experts who shared their knowledge (1,300+ references), to our brilliant illustrator Olga Posukh and multiple editors. The book indeed turned out to be the one to be proud of! Self-published on Amazon, the book is available in kindle epub (it's free if you have Amazon Prime or Kindle Unlimited), paper back and hard cover. Go check it out, rate and leave your reviews—this will help us spread the longevity meme greatly!

I’m running a survey to learn who introduced most people to longevity field. You must have learned about Rapamycin, naked mole rat, and hallmarks of aging from someone, right? Maybe this was a personal interaction, maybe you read their book, listened to podcast? I want to build a network and establish its most influential nods. I’d really appreciate if you share your story and ask your longevity friends to do the same. If we want the longevity meme to spread, it seems important to learn how WE ended up being under its influence. If collected enough data, I’ll share the results at the Policy & Media week of VitalistBay in May. If not then, than later :)

Guys, we are starting a new meme contest! The theme is popular objections to life extension https://x.com/OpenLongevity/status/1886523503798895072 Participate on 𝕏, repost, spread the word! We all need these memes badly 😄

A review of our recent article https://www.lifespan.io/news/combining-treatments-against-multiple-hallmarks-of-aging/

Age Reversal Unity filed a citizen petition to FDA demanding to classify “aging” as a “disease” 🦠. FDA posted the citizen petition here for public comments: https://www.regulations.gov/document/FDA-2024-P-2482-0001 I hope you go there and submit a comment supporting that aging should be classified as a disease by FDA. So far, the citizen petition got 48 comments. If the citizen petition gets 1,000 comments, FDA would most likely classify aging as a disease. We need 5 comments today:) Thank you

Vitalism Foundation is hosting The Longevity State Conference, a curated first-of-its-kind event focused on longevity states & how to hasten their emergence. -50/50 workshops + talks -longevity resort venue -accommodation and food incl. The number of spots is limited, and they are filling up quickly. Hurry up!

LBF has published its plan to defeat aging: https://www.longbiofellowship.org/roadmap

“I was always looking for ways to meaningfully improve people’s lives. For instance, I worked a lot with gifted children. At some point, I realized that no matter how well we do, in the end, frailty, disease, and death await everyone. Aging spares no one, be it businessmen, governors, farmers, it’s like an arch-problem.” An interview with @MishaBatin, one of the co-founders of Open Longevity & Say Forever! movement.

Martin Borch Jensen (CSO at Gordian Bio) is looking for Scientific Chief if Staff: “Work directly with me as our Scientific Chief of Staff & be part of everything it takes to run a growing biotech. You'll have wide responsibilities, owning projects and culture improvements, organizing our teamwork, and helping me set the company strategy. The ideal candidate combines scientific training (eg a PhD but degree not required) with excellent organization and communication, proactive problem solving, and handling a lot of balls at once. Most of all you'd have good mind-meld with me, to absorb ideas and judgement fast. Read more and apply here. And can learn more about GordianBio, including our mission and unique technology here.”

The central effort in promoting life extension revolves around broadcasting scientific achievements in this field. The battle against aging often boils down to a newsfeed of scientific discoveries. Thousands of people, across various platforms like Twitter, review articles, and YouTube, relay what gerontology researchers have discovered. Among Longevity activists, there's a prevailing idea of alerting the public about the imminent discovery of anti-aging remedies. However, there's a problem. This approach isn't really effective. The efficiency of such popularization is probably less than 1%. Discussions about a few molecules and their interactions related to aging lead nowhere. There are millions of such publications. It's like a chewing gum that people have been chewing for decades. How many interviews with leading experts do we need to realize that they have minimal impact? I'm not against scientific news, interviews, or statements on the necessity of life extension. I strongly support them, but they are insufficient. This activity becomes harmful if we focus solely on it, as it drains the energy and strength needed for change. It creates an illusion of progress, as if we've convinced someone to take action. If we had a metric for social change, we would see the minimal impact of such work. People are not rational. In a rational world, one interview, one lecture, one book would be enough to make life extension a universal social task. Moreover, in a society that accepts death, there are groups with entirely different interests, monopolizing resources and reluctant to allocate them to life extension. There are people, knowingly or unknowingly, who promote death. Even under the banners of health preservation and life extension, there can be enemies whose true interest is personal enrichment. Selling promises of immediate life extension works well, even for non-effective remedies. Overcoming tradition, stereotypes, and indifference involves incredibly complex tasks, the solutions to which are not just about listing aging science achievements. Clearly, we need a different approach in the public sphere. How? Raise the level of abstraction, introduce new categories, use models of social processes, gather and analyze new types of data. What's the first step? Change the language in which we discuss these problems. Introduce new categories, describe reality anew. Like in mathematics, where we can't solve a vast class of problems using only arithmetic and require differential and integral calculus. Like in physics, where we need a counterintuitive view of the world, where the passage of time depends on the speed of movement, or events in the quantum world completely contradict common sense. But this brings us closer to understanding the nature of reality. Rationalists, in solving their problems, introduced several concepts, particularly CEV (coherent extrapolated volition) — how future AI will extrapolate our values. Effective altruists think in terms of calculating expected utility and overlooked efficient ways of doing good. Whenever we face complex new tasks, we need new categories, essentially a new language, to solve this new challenge. What specific categories do we need? We need a measure of readiness to act in the fight against death. The degree of obsession. Characterize the strength and types of connections between community members. It may turn out that the most effective activity in the fight against death is to increase the connectivity of the Longevity community. We need to characterize the Longevity field itself, its structure, types of changes, and development dynamics. I will write more about these and other categories. Perhaps 90% of the ideas won't find agreement with the reader. But I can state from my experience that without a new language, a new picture of reality, metrics of social changes, and new categories, we will stagnate. We urgently need to create this.

From Karl Pfleger’d LinkedIn: Data from the new TargetD trial suggests that prior vitamin D trials were flawed. Many people, even professionals, still think vitamin D was a false profit that was disproven by big RCTs. This view is very flawed, for several reasons. A brief history: For decades, thousands of studies have shown reliable correlation of low vitamin D levels & bad health outcomes. Scientifically, the proper way to test the hypothesis that this correlation is causal is RCTs that meaningfully alter the low vitamin D status & then measure outcomes. Heaney in 2014 published trial design guidelines for nutrients saying essentially the above. Rule 4 was "The hypothesis to be tested must be that a change in nutrient status (not just a change in diet) produces the sought-for effect." This trial design guideline was repeated in 2018 specifically for vitamin D by Grant et al. But almost every negative vitamin D trial violates these guidelines & fails to properly scientifically test the hypothesis. In 2020 Boucher specifically & directly addressed this issue in a short paper, "Why do so many trials of vitamin D supplementation fail?" Common simple D RCT flaws: - Not starting w/ subjects w/ low levels. - Not using high enough dose to meaningfully change status (eg resolve deficiency). Esp true w/ overweight subjects who need higher doses. - Not waiting long enough for levels to rise before measuring outcomes. Now a new trial called Target-D tries to do the right thing by repeatedly testing 25OHD until a prespecified target (40ng/ml) is achieved & early data presented at American Heart Association's Nov'23 meeting vindicates the criticisms of the prior trials. Outcome data not mentioned (prob not avail yet) but data f/ early dosing still shows the issues: On dose: "90% [of subjects] required some level of Vitamin D dosing. Of those, 86.5% required more than 2000 IU daily [VITAL study dose] and 14.6% required more than 10,000 IU daily" On how long it took: "Less than 65% achieved over 40 ng/mL at three months. Another 25% of patients required six months or more of dosing titration" So longer than most D RCTs wait to measure outcomes, usually w/o testing levels achieved. Shows mid-trial testing is important. "Our findings here show that just giving patients some Vit D does not help them achieve optimal levels" Just b/c a trial is big doesn't mean it answers the right question. Most failed D trials don't negate the hypothesis that raising levels f/ low to sufficient improves health.

The first real antiaging drug has just received FDA approval: "Today, I’m so proud to announce that Loyal has earned what we believe to be the FDA’s first-ever formal acceptance that a drug can be developed and approved to extend lifespan. In regulatory parlance, we have completed the technical effectiveness portion of our conditional approval application for LOY-001’s use in large dog lifespan extension. As there was no established regulatory path for a lifespan extension drug, we had to design from scratch a scientifically strong and logistically feasible way to demonstrate efficacy of an aging drug. This process took more than four years, resulting in the 2,300+ page technical section now approved by the FDA. It included interventional studies of LOY-001 in an FDA-accepted model of canine aging and an observational (no-drug) study of 451 dogs. Our interventional studies with LOY-001 showed that the drug improved clinically-relevant aging parameters. We assessed these in laboratory studies using a dog model that represents accelerated aging. We then correlated those results with quality of life scores in the observational study, as independently measured by dog owners, and health outcomes as measured by veterinarians. This was key to show that the biological benefits of the drug are linked to clinically relevant outcomes. From our data, the FDA believes LOY-001 is likely to be effective for large dog lifespan extension in the real world. Once we satisfactorily complete safety and manufacturing sections and other requirements, vets will be able to prescribe LOY-001 to extend the lifespan of large dogs while we complete the confirmatory pivotal lifespan extension study in parallel." ~ Celine Halioua, founder of Loyal

Check out Aaron King’s project: “It took longer than it should have, but Agerank.com is now functional. It's not done but at least it's shareable. "If it changes with age, it's part of aging." Search for biomarkers in the top bar, use demographic filters in the left bar. Input your own data using the Plot function next to each scatterplot, add more datapoints with +. Swap medical ranges and underlying scatterplot info using the dropdown menus. What it does: - Shows most of the NHANES biomarkers in the context of age. How does each biomarker change over the lifespan, what is the variance, what are some medical ranges that exist for that biomarker. - Allows you to input your own data to see if you are beating the curve. - Allows you to swap between various years of NHANES data, not all data has been put in yet. - Has demographics filters for gender, ethnicity, BMI, and wealth. - Displays floating point mean (red) and median (black) Now I have a list of all the biomarkers that change with age, at least biomarkers from NHANES. I've discovered that 6 biomarkers are pretty much explained by obesity, so if you don't get fat these 6 will not change over your life. Another 8 respond to obesity but are not fully explained by it. At least 178 biomarkers in the system so far. More incoming.”

📹 Streaming now: Our seminar on aging evolution with Peter Lidsky! Dive into a critical analysis of mainstream aging models and discover Lidsky's unique perspective on aging as an adaptive mechanism for disease control. Join the discussion! https://youtube.com/live/ubzZHN_t-l4

Nastya Egorova: Made a very important step towards decentralized clinical trials with these wonderful ppl the other day aka built a Telegram bot for trial participants. We also took the🥇at the #DeSci track at #ZuConnect hackathon🤓 love you guys, excited to build this thing (and the whole infrastructure) bigger🙌 Zuzalu community and web3 in general are perfect to make such initiatives finally happen🚀

Aging is a paradox. A squirrel can live for 20 years, while the rat - only for two years, and we do not know why. Birds and bats live very long for their body sizes. The termite queen can live for many decades, while the worker termite is short-lived while having the same genome. Naked mole rats are barely age at all, while some carnivorous marsupials and Pacific salmons die very soon after reproduction, and we don't why. Aging is a routine part of our existence but it does not have a scientific definition. We know that bad things happen to organisms as they age, but what exactly happens and why, remains obscure. If we ask different experts what aging is, they will give us different answers. The consensus around this question is missing. In this seminar, we will discuss the strengths and the weaknesses of the mainstream models explaining the evolution of aging. Peter will present his alternative model, which suggests that aging evolved as an adaptive mechanism to control the spread of infectious diseases. us06web.zoom.us/j/84240186900

Halloween is on the horizon, and this month, we're drawing inspiration from the Day of the Dead. Let's gather at the Ferry Bld in San Francisco on Saturday, October 28 at 4 PM. For now we are planning to walk to the Fisherman's Wharf or Presidio along the embankment. Event Concept is Expelling the Inner Death. We will conduct a symbolic exorcism ritual, channeling energy to challenge the belief that death is our ultimate destiny. In an age marked by revolutionary breakthroughs, from genome-editing therapies to cellular reprogramming, we're redefining our relationship with mortality. As societal perceptions shift, ceremonies like ours capture the essence of this transformation. The strength of our gathering magnifies the magic we can create. Circle this date on your calendar and be part of this transformative event. Own a coffin? Feel free to bring it. Or any other emblem that represents your reflections on death or your stand against it. Costume Call: To effectively illustrate the concept of expelling death from our lives, we're calling for 2 costume themes: 🎃Dress in costumes that encapsulate deeper connotations of death—whether it's damaged mitochondria, cholesterol, genetic mutations, or society's evolving views on mortality. 🎃Dress in costumes of characters that expel death in different cultures, existing or fictional: monks, shamans, priests, elve healers, etc. Bring tambourines and other music instruments that can help assist with the rituals and attract attention. Raise your anti-death banners and bring posters that celebrate life. We'll also be collecting signatures for the Dublin Longevity Declaration. With video recording in place, we aim to make this event unforgettable. Want a deeper involvement? If you're interested in assisting with event preparations and organization, don't hesitate to get in touch. Together, let's make this Halloween a symbol of hope for scientific approach, and a declaration of triumph over death within ourselves. LinkedIn Facebook

The first Baltics Conference on Healthy Longevity, organized by the Longevity Alliance Baltic (LAB) will take place on 25 November 2023 (11.00-17.00) in the Latvian University – House of Nature, in Riga, Latvia. Some of the leading longevity researchers and advocates in the Baltic area and internationally will take part. Hopefully, this conference will help increase the awareness about longevity research and help build up the longevity community in the Baltic region, catalyzing a further development of the longevity field internationally. Details and registrations are in the link. The attendance is free, but registration is requested. The program is preliminary and changes may be possible. Thanks for spreading the word! http://longevitybaltics.org/conference/