PHARMACOLOGY HUBs

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144.explanation Correct Answer - A Ans. is 'a' i.e., Inhibits DNA dependent RNA synthesis. *The anticancer antibiotics are Actinomycin - D (Dactinomycin) Daunorubicin (Rubidomycin) Mitomycin C Doxorubicin Mitoxantrone Mithramycin (plicamycin) Bleomycins *These anticancer, antibiotics obtained from micro-organisms and have prominent antitumour activity. Mechanism of action : They are intercalated between DNA strands and interfere with its template function. *Actinomycin `D' inhibits DNA dependent RNA synthesis. *Bleomycin cause DNA breakage and free radical formation . *Doxo-and daunorubicin inhibit Topoisomerase I & II. *Mitomycin acts like alkylating agents. *Mitoxantrane binds to DNA to produce strand breakage and inhibits both DNA & RNA synthesis. **Remember *All antitumor antibiotics are cell cycle nonspecific except for bleomycin which acts in G2 phase. Join @PHARMACOLOGYhubs

143.explanation Correct Answer - D Ans. is `d' i.e., It is the drug of choice in treatment of acute mania. Atypical antipsychotics —> Olanzapine, risperidone, aripiprazole or quetiapine with or without benzodiazepine is the treatment of choice for acute mania. *Aripiprazole Only antipsychotic with D2 agonistic activity. (all others are D2 antagonists). •Longest acting It also has 5HT,A agonistic and 5HT2 antagonistic activity - Also known as dopamine-serotinine stabilizer. It is least sedating antipsychotic → can cause insomnia. Join @PHARMACOLOGYhubs

142.explanation Correct Answer - C Ans. is 'c' i.e., Intranuclear receptors. Join @PHARMACOLOGYhubs

141.explanation Correct Answer - C Ans. is 'c' i.e., IL 2 receptor blocker *Monoclonal antibodies (daclizumab and basiliximab) that block the interleukin 2 receptor and are used in prevention of graft rejection as immuno suppresant. Join @PHARMACOLOGYhubs