Pharmacology USMLE books and videos 2026

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Channel name was changed to «Pharmacology USMLE books and videos 2026»

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Educational objective: Tay-Sachs disease is an autosomal recessive disorder caused by [3-hexosaminidase A deficiency, which results in GM2 ganglioside accumulation. Key clinical features include progressive neurodegeneration and a cherry-red macular spot. In contrast to patients with Niemann-Pick disease, those with Tay Sachs disease have no hepatosplenomegaly.

Accumulation of which of the following metabolites is most likely present in this patient's tissues?