Derma sce dr .lana

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Wolf’s Isotopic Response 👉 Definition: A new, unrelated skin disease appears exactly at the site of a healed dermatosis. 👉 Classic trigger: Most often after healed herpes zoster scars. 👉 Second diseases reported (remember “Great King Loves Smart And Loyal Tough Warriors Make Strong Brave Soldiers”): • Granuloma annulare • Kaposi sarcoma • Leukemia cutis • Sarcoidosis • Acne • Lichen planus • Tinea • Warts (verruca plana) • Molluscum contagiosum • Squamous cell carcinoma • Basal cell carcinoma • Skin cysts (epidermoid) ⸻ So just remember: “After Zoster heals, the Wolf brings new soldiers: Granuloma, Kaposi, Leukemia, Sarcoid, Acne, Lichen, Tinea, Warts, Molluscum, SCC, BCC, Cysts.”

Postzygotic activating mutation in GNAS is associated with all of the following except: Options: A- CALM (Café-au-lait macules) B- Precocious puberty C- Hypothyroidism (hyperthyroidism) D- Polycystic fibrous dysplasia E- FSH & LH are low Step 1: Understand the key concept – GNAS mutation • GNAS gene → encodes the Gs alpha subunit → activates cAMP pathway. • Postzygotic mutation → leads to mosaicism. • Classic disorder: McCune-Albright syndrome (MAS). ⸻ Step 2: Recall the clinical features of MAS McCune-Albright syndrome triad: 1. Café-au-lait macules (CALM) → often “coast of Maine” irregular borders. ✅ 2. Fibrous dysplasia of bone → can be polyostotic (many bones). ✅ 3. Endocrine hyperfunction (due to constitutive Gs activation): • Precocious puberty (most common in girls). ✅ • Hyperthyroidism ✅ • Growth hormone excess ✅ • Cushing syndrome sometimes • FSH & LH are normal or elevated if gonadotropin-dependent, but in MAS, precocious puberty is usually gonadotropin-independent, so FSH & LH are low ✅

Risk of retinopathy is greatest with chloroquine and does not exist for quinacrine

Probenicid is co-administered with penicillin to prolong its half-life through decreased renal tubular secretion when higher blood levels are warranted.