Study Medicine 📖🩺

Thrombin Time vs Reptilase Time

Full NCCN guidelines 2026

Pocket Medicine 🗞️💜 9th edition

ً

Academic sources KFSH 2026 https://drive.google.com/drive/folders/1drQ8E-PNCVb3Ef0S1pE0yxcnFDD3xTgx?usp=sharing Dr. Alfadel Alshaibani 2026 https://drive.google.com/drive/folders/1ZkWH7G4qX63sQI5ZNTlrm8OqnfWXXmn6?dmr=1&ec=wgc-drive-%5Bmodule%5D-goto KFSH 2025 https://1drv.ms/f/c/d0d0de2fa94d8f8d/Eo2PTakv3tAggNCiYAAAAAAB-Nc8qrpWwSLOrYDe2mpaPA Reviews https://u.pcloud.link/publink/show?code=kZ3y4RVZTz5ORkUkX2hVNC1owywVpXdOIO9V#

https://file.kfshrc.edu.sa/portal/r/l/a568e59ae376418ab5ec0f5eacf23935 2025 KFSHRC Hematology Board Review Password 123456789 Old link not working anymore This is New link

B S H G u i d e l i n e Guidelines on the investigation and management of antiphospholipid syndrome

Emergencies in Hematology 🩸 Why, When and How I Treat

PNH Flow Cytometry

PNH

PNH

initial treatment of immune thrombotic thrombocytopenic purpura (TTP)

HANDBOOK OF HEMATOLOGIC MALIGNANCIES 📕📍

🧬 WHO 2025 Diagnostic Criteria – PV, ET, PMF🔴 Polycythemia Vera (PV) 🔹 Major: 1️⃣ Hb >16.5 g/dL (men) / >16.0 g/dL (women) OR Hct ↑ (>49% ♂ / >48% ♀) 2️⃣ BM: Hypercellular → trilineage growth (erythroid, myeloid, megakaryocytic) with pleomorphic MKs 🔬 3️⃣ JAK2 V617F / exon 12 mutation 🧪 🔹 Minor: Subnormal EPO ↓ ✅ Dx = All 3 Major OR (first 2 Major + Minor)🟠 Essential Thrombocythemia (ET) 🔹 Major: 1️⃣ Platelets ≥450 ×10⁹/L 🩸 2️⃣ BM: Proliferation of enlarged, hyperlobulated megakaryocytes 🔬 3️⃣ Not CML, PV, PMF, MDS, or other myeloid neoplasm ❌ 4️⃣ JAK2 / CALR / MPL mutation 🧬 🔹 Minor: Other clonal marker OR exclude reactive thrombocytosis ✅ Dx = All 4 Major OR (first 3 Major + Minor)🟣 Primary Myelofibrosis (PMF) 🔹 Major: 1️⃣ BM: Megakaryocyte atypia + reticulin/collagen fibrosis (≥2 overt, >1 pre-PMF) 🌲 2️⃣ Not CML, PV, ET, or MDS ❌ 3️⃣ JAK2 / CALR / MPL mutation (or other clonal marker) 🧬 🔹 Minor (≥1): Anemia 😴 ↑ WBC ≥11 ×10⁹/L Splenomegaly 🫛 LDH ↑ 🔥 Leukoerythroblastosis 🧪 ✅ Dx = All 3 Major + ≥1 Minor 💡 Exam Pearls 📝 PV hallmark → ↑RBC mass + JAK2 ET hallmark → Isolated thrombocytosis + driver mutation PMF hallmark → Fibrosis + splenomegaly + cytopenias Always rule out reactive causes first 🧾 📚 Reference: WHO 2016/2022, ASCO-SEP 2025, ASH-SAP 9th Ed.