JAMA (Journal of the American Medical Association)

A Review of Endometrial Cancer https://jamanetwork.com/journals/jama/fullarticle/2852744 To the Editor A recent Review offered a comprehensive overview of endometrial cancer, highlighting the emerging significance of molecular classification in informing prognosis and treatment, which reflects the growing role of molecular classification in clinical care. Nevertheless, the practical implementation of molecular classification was inadequately explored. Access to comprehensive molecular testing is inconsistent across health care systems. Even in high-resource settings, the availability of assays such as polymerase epsilon (POLE) sequencing is variable and result interpretation lacks standardization. These challenges are more pronounced in low-resource settings, resulting in a disparity between theoretical optimal care and real-world clinical practice.

“Nevus”: The Body as Text in Poetry https://jamanetwork.com/journals/jama/fullarticle/2852738 The body as text is among the richest and most enduring conceits in poetry—the idea that flesh, skin, and breath can be read, written upon, or themselves constitute a kind of language. Poets as diverse as Sappho, Walt Whitman, Pablo Neruda, Ellen Bass, and Patricia Smith have imagined the corporeal body as a form of expression or as a page upon which experience is inscribed. Physical attributes can become directions or landmarks on a map; anatomical features can be construed as metaphors; scars and wrinkles can be refigured as punctuation marks. It is unsurprising, then, that poetry written in response to medical experiences specifically should express such themes. Such is the case with “Nevus,” a poem in which the speaker sees his childhood retold in the various lesions his dermatologist assesses as she examines his skin. “She moves from mole to mole,/her dermatoscope hovering/above the surface of my pink planet,” it begins, immediately comparing the physical body with an entire world ready to be charted and read. Individual nevi come alive, “a small brain” or a cultivator of “two delicate hairs/as pets on my chest,” with their own mini narratives. The larger story of the speaker’s carefree childhood bodysurfing and suffering sunburns is recorded in a couple of more concerning moles. When the speaker returns to have these burned off, embodied memories are evocatively lost and yet remembered, much like a fire in a library can revise history, “all that fun so long ago,/the past just a small plume of ash.”

Total Intravenous vs Volatile Inhalational Anesthesia for Major Noncardiac Surgery Research Summary https://jamanetwork.com/journals/jama/fullarticle/2852737 This trial examined whether general anesthesia maintenance with total intravenous anesthesia (TIVA) improves patient outcomes compared with volatile-based inhalational anesthesia among adults aged ≥50 years undergoing major elective noncardiac surgery.

Diagnosis of Celiac Disease https://jamanetwork.com/journals/jama/fullarticle/2852746 This Insights discusses the diagnosis of celiac disease, including biopsy confirmation vs serology-based diagnosis, in children and adults.

Non–US-Born Physicians in the US Internal Medicine Workforce https://jamanetwork.com/journals/jama/fullarticle/2852745 This study estimates the share of US-born and non–US-born US medical graduates (USMGs) and international medical graduates (IMGs) in the US internal medicine workforce, as well as the share of underserved patients cared for by these physicians.

Error in Title https://jamanetwork.com/journals/jamaneurology/fullarticle/2852959 The Original Investigation titled “Management of Exacerbations and Rescue Therapy in the Phase 3 Myasthenia Gravis Inebilizumab Trial: A Prespecified Analysis of a Randomized Clinical Trial,” published online on August 10, 2026, was corrected to update the title from “Management of Exacerbations and Rescue Therapy: A Prespecified Analysis of the Phase 3 Myasthenia Gravis Inebilizumab Randomized Clinical Trial.” This article was corrected online.

Toward Precision Antiplatelet Therapy After Coronary Artery Bypass Grafting—Reply https://jamanetwork.com/journals/jamacardiology/fullarticle/2852857 In Reply We appreciate the insightful studies reported by Camera and Tremoli on the possibility of additional tailoring of intensity and duration of antithrombotic therapy after coronary artery bypass graft surgery (CABG) based on other biological determinants of the thrombotic risk that explain interindividual variability in the response to antiplatelet therapy.

Toward Precision Antiplatelet Therapy After Coronary Artery Bypass Grafting https://jamanetwork.com/journals/jamacardiology/fullarticle/2852858 To the Editor We read with great interest the recent Viewpoint by Sandner et al proposing a mechanistic framework to guide antiplatelet therapy after coronary artery bypass grafting (CABG). The authors argue that the intensity and duration of dual antiplatelet therapy (DAPT) should align with the temporal evolution of thrombotic risk, which is highest in the early postoperative phase and declines thereafter.

Vutrisiran Treatment and Cardiac and Amyloid Changes on MRI https://jamanetwork.com/journals/jamacardiology/fullarticle/2852859 This cohort study investigates if vutrisiran treatment was associated with longitudinal changes in cardiac structure, function, and amyloid burden in patients with transthyretin amyloid cardiomyopathy who were assessed with cardiovascular magnetic resonance imaging (MRI).