Neuroscience and Psychology

Changes in EEG and ECG signal connectivity during tilt table testing in healthy young adults without syncope https://bmcneurosci.biomedcentral.com/articles/10.1186/s12868-025-00982-4 Tilt table testing (TTT) has been used for over fifty years in clinical and basic medicine to study the adaptation of heart rate and blood pressure to changes in body position. In the area of studying local ...

Short- and long-term neurobehavioural impairments in mice offspring following chronic perinatal caffeine exposure and withdrawal https://bmcneurosci.biomedcentral.com/articles/10.1186/s12868-025-00981-5 This study explored neurodevelopmental and adult neurobehavioural outcomes in mouse offspring following chronic perinatal caffeine exposure and subsequent withdrawal. Healthy adult female BALB/c mice were mate...

Effects of different transcranial magnetic stimulation coil types on phosphene thresholds and their association with motor cortex excitability https://bmcneurosci.biomedcentral.com/articles/10.1186/s12868-025-00977-1 Phosphenes can be induced by applying transcranial magnetic stimulation (TMS) to the visual cortex. Since multiple factors influence phosphene perception, this study aimed to examine the effects of different T...

Dexmedetomidine pretreatment improves postsurgical delay in neurocognitive recovery in aged mice by inhibiting hippocampal microglial activation via activation of cholinergic anti-inflammatory pathways https://bmcneurosci.biomedcentral.com/articles/10.1186/s12868-025-00969-1 Perioperative use of dexmedetomidine (DEX) reduces the incidence of Delayed Neurocognitive Recovery (DNR) in elderly patients, though mechanisms remain unclear. This study investigated whether DEX improves DNR...

Long-term neprilysin gene transfer is associated with reduced levels of intracellular Abeta and behavioral improvement in APP transgenic mice https://bmcneurosci.biomedcentral.com/articles/10.1186/s12868-025-00980-6

Characterisation of the expression of P2X7 receptor, cancer stem cell markers and immunological mediators in human high-grade gliomas https://bmcneurosci.biomedcentral.com/articles/10.1186/s12868-025-00973-5 Glioblastoma is the most aggressive primary brain cancer. It is considered an ‘immunologically cold’ tumour where immune infiltrates are polarised to drive immunosuppression—and therefore tumour proliferation....

Publisher Correction: Mir-199a-3p aggravates neuroinflammation in an Alzheimer’s disease transgenic mouse model by promoting M1-polarization microglia https://bmcneurosci.biomedcentral.com/articles/10.1186/s12868-025-00974-4

Investigating topological alterations in procedural memory network across neuropsychiatric disorders using rs-fMRI and graph theory https://bmcneurosci.biomedcentral.com/articles/10.1186/s12868-025-00979-z Cognitive network dysfunction represents a core pathophysiological feature across major neuropsychiatric disorders, including Attention Deficit Hyperactivity Disorder (ADHD), bipolar disorder (BD), and schizop...

SRT1720 ameliorates LPS-induced depressive-like behaviors in mice and activates Parkin-mediated mitophagy https://bmcneurosci.biomedcentral.com/articles/10.1186/s12868-025-00968-2 Emerging evidence suggests a connection between mitophagy-a key mitochondrial quality control mechanism-and depression. Furthermore, sirtuin 1 (SIRT1), a NAD⁺-dependent deacetylase, has been implicated in the ...

Threat context impairs cognitive control of neutral words processing in social anxiety individuals: evidence from ERP and theta oscillations https://bmcneurosci.biomedcentral.com/articles/10.1186/s12868-025-00976-2 Social anxiety (SA) is characterized by cognitive control impairments, particularly in the processing of threat, yet how threat-laden environments modulate cognitive control over neutral stimuli remains unclea...

Comparative study of 18F-labeled PET radiopharmaceuticals in an Alzheimer’s disease mouse model https://bmcneurosci.biomedcentral.com/articles/10.1186/s12868-025-00978-0 Alzheimer’s disease (AD) is a progressive neurodegenerative disorder that is the leading cause of dementia, characterized by memory loss, cognitive decline, and significant social and economic burdens. Despite...

Altered theta oscillations in basolateral amygdala and ventral hippocampus related to social defeat https://bmcneurosci.biomedcentral.com/articles/10.1186/s12868-025-00972-6 Depression is a prevalent mental disorder, and prolonged exposure to social defeat is a major contributing factor in the onset of depression. Repeated social defeat stress (RSDS) is a commonly used animal mode...

Distinct neural circuits processing pleasant and unpleasant sounds: an fMRI-based approach https://bmcneurosci.biomedcentral.com/articles/10.1186/s12868-025-00975-3 Investigating how the human brain processes the emotional valance of sounds is critical for understanding sensory, emotional, and motor integration at the neurobiological level. The current study utilized func...

Hybrid molecule SA-10 and its PLGA nanosuspension protect human and rodent retinal ganglion cells against neuronal injury https://bmcneurosci.biomedcentral.com/articles/10.1186/s12868-025-00971-7 Glaucoma is a leading cause of blindness characterized by retinal ganglion cell (RGC) degeneration. SA-10, a dual-acting compound with ROS scavenging and NO-donating properties, was evaluated to enhance RGC su...

Visual change-related brain potentials elicited by changes in doll hair color in school-aged children https://bmcneurosci.biomedcentral.com/articles/10.1186/s12868-025-00970-8 Change-related brain responses are specifically elicited when the regularity of a continuous sensory stimulus is disrupted and are recorded by electroencephalography or magnetoencephalography. These responses ...

Effects of subanesthetic dose of ketamine on motor and cognitive outcomes of harmaline-induced essential tremor model: a focus on Lingo-1 and inflammatory pathways https://bmcneurosci.biomedcentral.com/articles/10.1186/s12868-025-00966-4 Essential tremor (ET) is a common neurodegenerative disorder characterized by action tremors and various non-motor symptoms. This study investigated the potential therapeutic effects of ketamine, an NMDA recep...

Structural changes of tubulin by interacting with Δ9-tetrahydrocannabinol: in-vitro and theoretical studies https://bmcneurosci.biomedcentral.com/articles/10.1186/s12868-025-00957-5 There is growing evidence of the contribution of microtubule dynamics to dendritic spine changes, synaptic plasticity, axonal transportation, and cell polarity. Besides, one of the well-studied effects of Cannabi...

Effects of repetitive mechanical tactile stimulation interventions with stationary and moving patterns on paired-pulse depression https://bmcneurosci.biomedcentral.com/articles/10.1186/s12868-025-00960-w Repetitive somatosensory stimulation (RSS) reduces paired-pulse depression (PPD), reflecting GABAergic inhibition in the primary somatosensory cortex (S1). This effect may vary by tactile stimulation pattern. ...

Mir-199a-3p aggravates neuroinflammation in an Alzheimer’s disease transgenic mouse model by promoting M1-polarization microgliaMir-199a-3p 通过促进 M1 极化小胶质细胞加重阿尔茨海默病转基因小鼠模型中的神经炎症 https://bmcneurosci.biomedcentral.com/articles/10.1186/s12868-025-00965-5 Chronic neuroinflammation, driven by M1-polarized microglia, is a core pathological mechanism of Alzheimer’s disease (AD). Elevated expression levels of miR-199a-3p and pro-inflammatory cytokines were detected...

Anatomical and behavioral characterization of three hemiplegic animal models https://bmcneurosci.biomedcentral.com/articles/10.1186/s12868-025-00961-9 Hemiplegia is characterized by muscle weakness on one side of the body, often resulting from damage to the brain, spinal cord, or associated nerves. This condition commonly occurs due to strokes, traumatic bra...