ToBeResearcher

کمیته های تحقیقات و فناوری دانشجویی دانشگاه های علوم پزشکی کلان منطقه ۸ کشور برگزار میکنند: 🚦مدرسه زمستانه مقاله نویسی ۱. آشنایی با مقالات Case report وCase series لینک ثبت نام : https://survey.porsline.ir/s/sAuZiFhA ۲. مقاله نویسی با هوش مصنوعی لینک ثبت نام: https://survey.porsline.ir/s/M3d7SsFJ 🚪لینک برگزاری ۱ و ۲: https://www.skyroom.online/ch/hosin1360/bioinformatics ۳. رفرنس نویسی مندلی لینک ثبت نام:  https://workshop.mubam.ac.ir 🚪لینک برگزاری: http://vc2.muba/research ۴. کارگاه آشنایی با مقالات سیستماتیک ریویو و متا آنالیز لینک ثبت نام: https://forms.gle/oYewGC55beBiu4SR8 🚪لینک برگزاری: https://vc.rums.ac.ir/research ۵. آشنایی با رفرنس نویسی اندنوت لینک ثبت نام:  https://workshop.mubam.ac.ir 🚪لینک برگزاری: http://vc2.mubam.ac.ir/research ۶. کارگاه آشنایی با مراحل مقاله نویسی اورجینال لینک ثبت نام: https://survey.porsline.ir/s/rsPHacXl 🚪لینک برگزاری: https://vc.rums.ac.ir/research ۷. نحوه ارزیابی روایی و پایایی پرسشنامه‌ها لینک ثبت نام: https://survey.porsline.ir/s/OkUoR53t ۸. نوشتن مقالات مروری ساده (narrative) و review Scoping لینک ثبت نام: https://survey.porsline.ir/s/BmhlTy4z ۹. نحوه طراحی مطالعات کیفی لینک ثبت نام: https://survey.porsline.ir/s/hhkavXjN 🚪لینک برگزاری۷، ۸ و ۹:  https://B2n.ir/kmuepid 📞راه‌های ارتباطی: @bam_src 🌱واحد اطلاع‌رسانی کمیته‌های تحقیقات و فناوری دانشجویی دانشگاه‌های علوم‌پزشکی بم

Beyond nutrition: Exploring immune proteins, bioactive peptides, and allergens in cow and Arabian camel milk Highlights • Pre-fractionation with 0.4 % SDS enhanced milk protein identification. • Enrichment as cream yielded the highest number of immune system-related proteins. • A straightforward filtration enriched native bioactive peptides efficiently. • Camel milk comprised more native and tryptic bioactive peptides than cow milk. • As camel milk lacks beta-lactoglobulin, it is potentially less allergenic. https://www.sciencedirect.com/science/article/pii/S0308814624041219 https://t.me/ToBeResearcher

Harsh parenting trajectories from childhood through adolescence and socioemotional competences at age 18: 2004 Pelotas Birth Cohort Study Highlights • We identified three trajectories of harsh parenting in the cohort participants. • A high harsh parenting trajectory was linked to worse socioemotional competences. • Those who experienced high harsh parenting exhibited lower scores of self-esteem. • High harsh parenting was linked to worse emotion regulation and prosocial behaviour. • A high harsh parenting trajectory was related to more peer relationship problems. https://www.sciencedirect.com/science/article/abs/pii/S0165032724013405 https://t.me/ToBeResearcher

Xenon gas could protect against Alzheimer’s disease! The study found that Xenon gas inhalation suppressed neuroinflammation, reduced brain atrophy, and increased protective neuronal states in mouse models of Alzheimer’s disease. Results are published in Science Translational Medicine, and a phase 1 clinical trial of the treatment in healthy volunteers will begin in early 2025.   “It is a very novel discovery showing that simply inhaling an inert gas can have such a profound neuroprotective effect,” said senior and co-corresponding author. “One of the main limitations in the field of Alzheimer’s disease research and treatment is that it is extremely difficult to design medications that can pass the blood-brain barrier—but Xenon gas does. We look forward to seeing this novel approach tested in humans.”   https://t.me/ToBeResearcher

Automated diagnosis of respiratory diseases from lung ultrasound videos ensuring XAI: an innovative hybrid model approach Our model TD-CNN-LSTM-LungNet attained a remarkable accuracy of 96.57% in classifying LUS videos into pneumonia, COVID-19, normal, and other lung disease classes, which is above compared to ten traditional transfer learning models experimented with in this study. The eleven-ablation case study reduced training costs and redundancy. K-fold cross-validation and accuracy-loss curves demonstrated model generalization. The DSS, incorporating Layer Class Activation Mapping and heatmaps, improved interpretability and reliability, and PDF graphs facilitated precise decision-making by identifying feature boundaries. The DSS facilitates clinical marker analysis, and the validation by using the proposed algorithms highlights its impact on a reliable diagnosis outcome. https://www.frontiersin.org/journals/computer-science/articles/10.3389/fcomp.2024.1438126/full https://t.me/ToBeResearcher

PFAS biodegradation by Labrys portucalensis F11: Evidence of chain shortening and identification of metabolites of PFOS, 6:2 FTS, and 5:3 FTCA Highlights • Bacterial defluorination and chain shortening of PFOS, 6:2 FTS, 5:3 FTCA occurred • PFOS removal of up to 96 % was observed after a 194-day incubation period • After 100 day-incubation, up to 58 % of 5:3 FTCA and 21 % of 6:2 FTS were removed • Several defluorinated PFOS metabolites were detected during biodegradation https://www.sciencedirect.com/science/article/abs/pii/S0048969724085061 https://t.me/ToBeResearcher

Life expectancy by county and educational attainment in the USA, 2000–19: an observational analysis Nationally, in all years there was a clear educational gradient in life expectancy at age 25 years where those with higher levels of education had higher life expectancy: individuals who had completed a college degree had higher life expectancy compared with those who had completed some college education (by 0·3 to 2·0 years over the study period), those who had completed some college had higher life expectancy than the high-school graduate population (by 4·1 to 4·9 years over the study period), and those who had graduated high school had higher life expectancy than those with less than a high-school education (by 3·4 to 5·1 years over the study period). From 2000 to 2019, life expectancy increased by 2·5 years (95% uncertainty interval 2·4 to 2·6) for the college graduate population, 0·7 years (0·6 to 0·8) for the population who had completed some college, and 0·3 years (0·3 to 0·4) for the high-school graduate population; there was no net change for those with less than a high-school education (0·0 years [−0·1 to 0·1]). In every educational attainment population, life expectancy increased by more from 2000 to 2010, with diminishing gains or even declines from 2010 to 2019. Life expectancy varied at the county level; eg, in 2019, the IQR for the population with less than a high-school education was 67·4 to 72·1 years, whereas for the college graduate population it was 82·3 to 84·6 years among counties with unmasked estimates. The college graduate population had higher life expectancy than those who had completed some college in 1937 (81·1%) of 2389 counties (47·1% statistically significant), which in turn had higher life expectancy than the high-school graduate population in 2726 (97·7%) of 2791 counties (87·0% statistically significant), which in turn had higher life expectancy than the population with less than a high-school education in 2356 (95·9%) of 2456 counties (91·6%). Over the study period, the gap in life expectancy between the college graduate population and those with less than a high-school education grew in 2594 (84·8%) of 3060 counties. https://www.thelancet.com/journals/lanpub/article/PIIS2468-2667(24)00303-7/fulltext https://t.me/ToBeResearcher

Emotional support across adulthood: A 60-year study of men’s social networks. Past research shows that social networks get smaller with age. But not all types of relationships may shrink at the same rate or for similar reasons. In the present study, we used a unique data set from a sample of 235 men who were followed longitudinally for 71 years to examine how the general pattern of network shrinkage documented in previous research generalizes to the number of emotional support providers in people’s networks. We additionally examined early-life predictors of the size of later-life support network. Growth curve analyses revealed that, mirroring the more general pattern of network shrinkage, emotional support networks shrink by as much as 50% between the ages of 30 and 90, reflecting an average reduction from two to one support providers. Examining the associations between prospectively collected measures of childhood family environment and later-life emotional support, we also found that men who grew up in warmer family environments had larger support networks in adulthood. In contrast, childhood family socioeconomic status was not connected to the size of emotional support networks later in life. The generalizability of this work is limited by the use of an archival all-male sample from the United States. Despite this limitation, these findings make important contributions to our understanding of adult socioemotional development and underscore the importance of prospectively collected longitudinal data in developmental research. Additional research is needed to examine the consequences of changing emotional support across the lifespan for health and well-being. https://psycnet.apa.org/doiLanding?doi=10.1037%2Fpag0000843 https://t.me/ToBeResearcher

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Stem cell therapy for knees 2025: fact-check, costs, risks Quick Article Summary and Claim Review. Stem cells are an unproven approach to knee problems like pain and arthritis, but many clinics claim it works and is safe. The cost of around $5,000-$10,000 at unproven stem cell clinics is generally not covered by insurance or Medicare. Overall, this experimental therapy may not be worth the cost and risks at this time. You should consult your doctor. https://ipscell.com/2025/01/stem-cell-therapy-for-knees-2025-fact-check-costs-risks/ https://t.me/ToBeResearcher

The future of cancer immunotherapy will come through mitochondria: Cancer cells hijack T cells A study reveals how cancer cells suppress immune responses by transferring mutated mitochondria to tumor-infiltrating T cells. Researchers identified mitochondrial DNA mutations in T cells that matched mutations in the cancer cells they infiltrated. This transfer impaired T cell metabolism and function, leading to senescence and a diminished ability to fight tumors. The transfer occurs via tunneling nanotubes and extracellular vesicles, with cancer-derived mitochondria resisting normal degradation processes. These dysfunctional mitochondria disrupt T cell energy production, leaving the immune cells unable to mount effective antitumor responses. The findings could explain why some patients fail to respond to immune checkpoint inhibitors like PD-1 blockers. Targeting this mitochondrial transfer mechanism might open new doors for the future of cancer immunotherapy. A dedicated workshop on mitochondrial transfer and its implications for cancer therapy will be organized at Targeting Mitochondria 2025. https://wms-site.com/press-media/1313-the-future-of-cancer-immunotherapy-will-come-through-mitochondria-cancer-cells-hijack-t-cells https://t.me/ToBeResearcher

Mitochondrial swap from cancer to immune cells thwarts anti-tumour defences Immune cells can destroy cancer, but tumours often evade such responses. The bidirectional transfer of mitochondria between cancer and immune cells is a newly discovered mechanism that thwarts anticancer defences. https://www.nature.com/articles/d41586-025-00077-4 https://t.me/ToBeResearcher

Long COVID Impairs Exercise Capacity and Cognition for Years A study of nearly 1,000 people with post-COVID-19 syndrome (PCS) revealed that two-thirds still experienced significant symptoms, including reduced exercise capacity and cognitive performance, two years after infection. Persistent symptom clusters included fatigue, neurocognitive disturbances, and post-exertional malaise, with worse outcomes in individuals with obesity, lower education, or severe initial infections. https://dx.doi.org/10.1371/journal.pmed.1004511 https://t.me/ToBeResearcher

Data-driven discovery of associations between prescribed drugs and dementia risk: A systematic review Highlights ·We present a systematic review of studies reporting association between drugs prescribed for other conditions and risk of dementia including 139 million people and 1 million cases of dementia. ·Our work supports some previously reported associations, for example, showing decreased risk of dementia with drugs to treat inflammatory disease and increased risk with antipsychotic treatment. ·Antimicrobial treatment was perhaps more surprisingly associated with decreased risk, supportive of recent increased interest in this potential therapeutic avenue. ·Our work should help prioritize drugs for entry into adaptive platform trials in Alzheimer's disease and will serve as a useful resource for those investigating drugs or classes of drugs and risk of dementia. https://alz-journals.onlinelibrary.wiley.com/doi/10.1002/trc2.70037 https://t.me/ToBeResearcher

Association of muscle strength and cardiorespiratory fitness with all-cause and cancer-specific mortality in patients diagnosed with cancer: a systematic review with meta-analysis High muscle strength and CRF were significantly associated with a lower risk of all-cause mortality. In addition, increases in CRF were associated with a reduced risk of cancer-specific mortality. These fitness components were especially predictive in patients with advanced cancer stages as well as in lung and digestive cancers. This highlights the importance of assessing fitness measures for predicting mortality in cancer patients. Given these findings, tailored exercise prescriptions to improve muscle strength and CRF in patients with cancer may contribute to reducing cancer-related mortality. https://bjsm.bmj.com/content/early/2025/01/03/bjsports-2024-108671 https://t.me/ToBeResearcher

انستیتو تحقیقات تغذیه و صنایع غذایی کشور، دانشگاه علوم پزشکی شهید بهشتی برگزار می نماید: 📣 نخستین جشنواره دانشجویی کشوری پژوهش و فناوری صبا (صنایع غذایی، بهداشت و ایمنی مواد غذایی) 🗓 زمان و مکان برگزاری: سه شنبه ۳۰ بهمن ماه ۱۴۰۳ ساعت ۹ الی ۱۲ انستیتو تحقیقات تغذیه و صنایع غذایی کشور 📌 مهلت ارسال آثار تا ۱۵ بهمن ۱۴۰۳ 🗳 ارسال مستندات: rtffsiran@gmail.com ✅ پاسخگویی سوالات: 🆔 @Kimia_Norouzi 🆔 @FooddScience

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New cell therapy raises hope for curing type 1 diabetes – "Never succeeded before" In a first-in-human study at the ATMP center at Uppsala University Hospital in Sweden, the world’s first transplantation of genetically modified, hypoimmune insulin-producing cells from the islets of Langerhans has been used as a treatment. The key aspect is that the transplantation was carried out without immunosuppression. The hope is that, in the long term, this patient group could be cured of type 1 diabetes. The American company Sana Biotechnology, which developed the hypoimmune technology, saw its stock soar after the first results were presented this week. The company’s shares rose by approximately 200 percent. For individuals with severe type 1 diabetes, a well-established treatment involving transplantation of islets of Langerhans, a type of cell cluster containing insulin-producing cells, has been available for over 20 years. This treatment involves isolating islets of Langerhans from a deceased donor's pancreas and transplanting them into a diabetes patient with the goal of achieving normal blood sugar control and independence from insulin. However, the transplantation has required immunosuppression in the patient, which often leads to side effects and is not suitable for everyone. https://www.lifesciencesweden.se/article/view/1138864/new_cell_therapy_raises_hope_for_curing_type_1_diabetes_never_succeeded_before https://t.me/ToBeResearcher

Associations between different coffee types, neurodegenerative diseases, and related mortality: findings from a large prospective cohort study Background Observational studies have suggested associations between amount of coffee consumption and decreased risk of neurodegenerative diseases. However, these studies do not consider differences among coffee types, including sweetened, unsweetened, caffeinated, and decaffeinated varieties. Objectives This study aims to identify associations between the consumption of various coffee types (sugar-sweetened, artificially sweetened, unsweetened, caffeinated, and decaffeinated) and risks of Alzheimer’s disease and related dementias (ADRD) and Parkinson’s disease (PD), along with related mortality. Methods This prospective study included 204,847 participants (44.7% males) from the UK Biobank. Cox proportional hazards models were used to assess the associations of coffee type with neurodegenerative outcome. On the basis of coffee consumption, participants were divided into 5 groups: non-coffee consumers, >0–1 cup/d, ≥1–2 cups/d, ≥2–3 cups/d, and ≥3 cups/d. Results Over a median follow-up of 9 y, the study documented 1696 cases of ADRD, 1093 cases of PD, and 419 neurodegenerative-related deaths. In the multivariate analysis, compared with non-coffee consumers, those with the highest intake of unsweetened and caffeinated coffee (≥3 cups/d) showed hazard ratios (95% confidence intervals) of 0.75 (0.62, 0.91) for ADRD, 0.71 (0.56, 0.91) for PD, and 0.67 (0.44, 1.01) for neurodegenerative-related death. However, no significant associations were noted in either decaffeinated or sugar/artificially sweetened coffee groups (P > 0.05). https://www.sciencedirect.com/science/article/abs/pii/S0002916524006713 https://t.me/ToBeResearcher